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Wellness Wednesday for January 14, 2026

The Wednesday Wellness threads are meant to encourage users to ask for and provide advice and motivation to improve their lives. It isn't intended as a 'containment thread' and any content which could go here could instead be posted in its own thread. You could post:

  • Requests for advice and / or encouragement. On basically any topic and for any scale of problem.

  • Updates to let us know how you are doing. This provides valuable feedback on past advice / encouragement and will hopefully make people feel a little more motivated to follow through. If you want to be reminded to post your update, see the post titled 'update reminders', below.

  • Advice. This can be in response to a request for advice or just something that you think could be generally useful for many people here.

  • Encouragement. Probably best directed at specific users, but if you feel like just encouraging people in general I don't think anyone is going to object. I don't think I really need to say this, but just to be clear; encouragement should have a generally positive tone and not shame people (if people feel that shame might be an effective tool for motivating people, please discuss this so we can form a group consensus on how to use it rather than just trying it).

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Reposting because I dropped this in the last Wednesday thread on a Tuesday like a dummy.

Could anyone direct me to some good posts about antidepressants? Effortposts about their efficacy, personal experience, I'm not picky. I tried to find some but Google wasn't much use and I can't figure out how to search the site specifically (permanent lurker here, sorry).

I was on Bupropion for 2 years about a decade ago. For the first year it was helpful in managing a depression that manifested with lots of fatigue. It gave me the energy to make lifestyle changes that improved it long term. During the second year it began causing unmanageable anger issues and I eventually stopped. Ever since then my lifestyle changes and talk therapy have managed it reasonably well.

Lately it's been getting worse and I'm considering going back on antidepressants. The main issue is that unambiguously good events exacerbate my depression and that has historically led to me sabotaging myself. I have some major life events coming up in the next couple years and would like some emotional stability. I have a psych eval tomorrow and I was hoping for some advice, feedback, pointed questions to ask the psychiatrist, stories, anything really. Even some google-fu advice to find better scientific information about this instead of feel-good self help articles made by AI or journalists who are about as smart as current AI without the work ethic. Do I even need antidepressants, or is this some weird Pavlovian issue that I can work on without them?

You need a psychiatrist. I am only two-thirds of one, but fortunately for you, I've got exams and that means actually reading some of the papers.

(Please see an actual psychiatrist)

The choice of initial antidepressant is often a tossup between adherence to official guidelines, clinical judgements based on activity profile and potential side effects, and a dialogue with the patient.

In short? It is usually not very helpful to worry too hard about the first drug. They're roughly equally effective (and where one is superior, it's by a very slim margin) But in certain situations:

  • Can't sleep? Lost appetite? Mirtazapine
  • Too sleepy? Already gaining weight? Absolutely not mirtazapine, consider bupropion or vortioxetine
  • Afraid of sexual side effects? Bupropion or vortioexetine again, mirtazapine too
  • Tried an SSRI and it didn't help? It's better to try a different class of antidepressant instead of just another SSRI, and so on.

(But before the meds, a physical checkup is mandatory, as are investigations to rule out medical causes. You're going to feel depressed if your thyroid isn't working, or if you've got Cushing's.)

  • Antidepressants work. They beat placebo, but not by a massive margin.
  • Effects are synergistic with therapy.

Unfortunately, you haven't given me enough information to make an informed choice. I'd need to know about the severity of your depression, graded based on symptoms, lifestyle, overall health and a bunch of other things. Hopefully your actual doctor will do their due diligence.

Man you are either an irredeemable slopmonger or spending so much time immersed in slop that your own writing is becoming indistinguishable.

Wow.

I guess we have to expand the taxonomy of LLM psychosis, to account for people so paranoid/blind that they see AI the moment someone bothers to use markdown formatting. If bullet points are all it takes to set you off, then one to the brain is probably the best possible cure.

I've always written like this. You're welcome to trawl my profile back to the days when LLMs were largely useless, and you'll find the same results.

And, for what it's worth, that comment was hastily typed out while in the midst of studying actual notes on antidepressant prescription according to UK guidance. You just can't win.

Guess what? The LLMs have read the same literature. There isn't much room to put some kind of unique human spin on the basics of choosing and switching between antidepressants. If ChatGPT had written it for me, it would have been thrice as long, and probably more comprehensive. In which case, I am flattered to be mistaken for it.

I've always written like this.

Dude, I've been on here... I don't remember actually, but a long time before I saw you show up. Taking your word that you aren't just feeding questions into the machine for whatever reasons -- your writing has become super ugly over the past six months or so. Your bluster only confirms that you've lost the plot as to what good writing even looks like.

(and you might want to read better if you think it's the bullet points)

Dude, I've been on here... I don't remember actually, but a long time before I saw you show up.

I'll save you the bother. We've both been on themotte.org since September 2022. I've been a user of /r/TheMotte since just after it split off from the CWR thread on /r/SSC.

And in the span of 3 years, the only notable events in your mod log are two warnings. Not a single AAQC, and people stumble into those by accident. I'll welcome your criticism about my writing style when you write something to impress me first. Or even impress anyone, I don't select the nominees, those are largely on the basis of popular opinion. It takes as little as one person hitting report.

When someone like @Amadan or @2rafa or @phailyoor or.... criticizes my writing style or my very limited use of AI (in this case, exactly zero), I listen. When I didn't even use the damn thing, I'm not going to care very much about your unfounded concerns. If you don't like the self_made_human house style, you're entirely at liberty to not read it.