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Chesterton's Pill

I.

I am not entirely sure how common it is to get so bored on vacation that you voluntarily return to your old workplace and accidentally start practicing medicine. Probably not very. But recently, thanks to certain flight disruptions in Dubai which I do not need to elaborate on, I found myself stranded at home in India far longer than anticipated.

I was going stir crazy. My parents, who maintain a baseline level of mild disappointment that I ever emigrated, suggested I go informally shadow the psychiatry department at my old hospital. "See what psychiatry is like at home," they said. "Maybe you will learn something."

I was already experiencing a profound disillusionment with psychiatric training in the UK, and my previous exposure to the Indian equivalent was highly idiosyncratic. During my internship at this same teaching hospital, my psych rotation had collided perfectly with the initial Covid lockdowns. Outpatient services were entirely shuttered. Any ward patient capable of bipedal locomotion was immediately discharged.

I spent those two weeks checking vitals in the female suicide ward and conversing with a very pleasant schizophrenic gentleman who had a hyper-specific obsession with light fixtures. He had been living on the ward for a decade (no next of kin and nowhere to send him after discharge except to the streets, and then the cops would drop him right back on our doorstep) and had somehow become a genuinely competent amateur electrician. I personally witnessed him replace multiple malfunctioning bulbs. He did very solid work.

So when my parents broached the idea of visiting, I agreed. It was mostly curiosity mixed with a bit of nostalgia. That intern year was almost certainly the worst year of my life, but people assure me this builds character. I thought it would be nice to show up as a glorified medical tourist and see what my Indian counterparts were up to.

II.

After pulling a few strings, I arrived at the outpatient department. It was exactly as crowded and poorly ventilated as I remembered, though stopping just short of actual asphyxiation. I located my point of contact, a second year postgraduate trainee, and optimized my posture to fit onto a partially vacant seat without crushing a colleague's purse.

The initial wave of patients presented with the classic poorly differentiated psychosomatic complaints that are the norm in developing countries. When your native language lacks a dedicated lexeme for "depression", psychological distress predictably routes itself through somatic channels. It manifests as a vague stomach ache or random peripheral tingling. We prescribed pregabalin, gabapentin, or amitriptyline, depending on mood, handwriting and the current phase of the moon. The patients were generally just thrilled to have seen a doctor at all.

Eventually, more interesting cases arrived. Because I was actively peering over my colleagues' shoulders, they generously suggested I take a crack at handling some of them myself. Sure, I thought. Why not?

I quickly came to regret this decision. I have a laundry list of complaints about British psychiatry, but I was not quite prepared for the reality of the Indian clinic.

First, the documentation varied from poor to completely nonexistent. My once finely honed ability to decrypt physician scribbles into valid pharmacological interventions had totally atrophied. Furthermore, the patients were terrible historians. I do not mean this as a moral failing; it is just a downstream consequence of local selection pressures. Government hospital care in India is free. This strongly selects for patients who are overwhelmingly poor, undereducated, and often separated from the physician by a formidable language barrier. Add the baseline communication difficulties of psychiatric patients, and taking a history feels like trying to reconstruct Herodotus from a copy that fell into a blender.

But it was a good challenge. I wanted to prove I could still read between the lines.

Almost immediately, I encountered a truly spectacular case of polypharmacy. We had a lady on lithium, valproate, and approximately a dozen overlapping medications. When were her lithium levels last checked? My best guess is shortly after the universe discovered helium-helium fusion. Thyroid function? The only confirmed fact was that she theoretically possessed a thyroid gland. She had coarse tremors, which could have been caused by literally any combination of the chemicals in her bloodstream. I consulted a senior resident, and we agreed to slash the regimen down to the bare minimum and demand some actual blood work before she returned.

III.

The cases only got weirder. Consider the medical tourist from Bangladesh. He had early onset schizophrenia, but he was relatively stable on his current regimen. Why had his parents brought him across an international border? They claimed they could not source brand name amisulpride in Bangladesh. A quick Google search suggested this was highly improbable, but here they were.

To make matters worse, the family was incredibly vague about his actual medication list. Besides his known antipsychotics and thyroxine, he apparently took a mysterious pill every morning. What was it for? They had no idea. What was it called? A mystery. What did it look like? It was a small tablet.

It is a miracle I did not tear my hair out. After another consult with the attending, we switched him to a more easily sourced variant of amisulpride and advised the family to stockpile six months of it before going home. As for the mystery pill, we essentially applied Chesterton's Fence to psychopharmacology. Chesterton's Pill was deemed structurally load bearing for this mixed metaphor. It clearly had not killed him yet, so we left it exactly as we found it.

My final patient was a six year old boy. His mother presented a constellation of complaints: he was hyperactive, liked staying up late, and lacked focus in class. It looked like a textbook case of ADHD. But given his age, I thought it was worth digging deeper. I learned he was functionally illiterate, possibly dyslexic, and his teacher had explicitly told the mother to get him evaluated.

Then the mother casually mentioned his "fright."

During normal daily activities, the boy would suddenly freeze. He would look incredibly distressed, and then he would get the human equivalent of the zoomies. He would sprint around the room. After the running stopped, he would approach his mother or older sister and bite them. Sometimes he bit hard enough to draw blood. He could not explain why he did this or what he experienced during the episodes.

I looked at him again. He was a perfectly normal, fidgety kid missing a few baby teeth. There were no obvious signs of hydrophobia, though I mentally filed rabies under "highly unlikely but technically possible."

I had absolutely no idea what I was looking at. I debated the case with a colleague. I suggested ADHD comorbid with Oppositional Defiant Disorder. My colleague argued against ODD because the kid was perfectly well behaved in the clinic. I countered that ODD typically manifests at home first, and is usually restricted to familiar adults. Then I floated the idea that his bizarre running and biting episodes might be complex partial seizures.

My colleague theorized it was an intellectual disability or learning disorder, perhaps part of a broader genetic syndrome. I shrugged. He was probably right. There might be a perfectly neat clinical label for this waiting in a dusty textbook somewhere. Or perhaps this is just another reminder that our diagnostic categories do not actually carve reality at its joints.

We eventually compromised. We prescribed clonidine to manage the behavioral symptoms and cover ADHD to a limited extent, then referred them to a clinical psychologist and an ENT specialist for good measure. I had spent more time on this one child than on my previous three patients combined, and the clinic was simply not built for that level of investigation.

I still have no idea what was actually wrong with him.

To avoid ending on a downer, I was happy to hear that the amateur electrician had, in fact, been discharged sometime in the past five years. None of the current trainees had heard of him. Right after I'd "treated" him? I'll take the credit, if no one's looking.

My parents, for what it's worth, were pleased I'd made myself useful. They remain cautiously optimistic about my eventual return.

I remain unconvinced, but I did find the pace to be California Rocket Fuel compared to my usual fare. Who knows? Maybe I'll get bored of making ten times the money, one day.

(You may, if you please, like and subscribe to my Substack. It's what all the cool kids are doing these days.

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Love your posts bro.

Doesn’t even matter the subject - it’s just enthralling.

Write a book.

And come to America, specifically Florida, I want to read your multi part write up dealing with our insurance, our minorities, and our whites.

E: absolutely insane that you still have a Reddit account that’s 11 years old. I find that sort of thing fascinating as well.

Love your posts bro.

Thanks <3, whatever level of homo is socially acceptable these days haha.

Write a book.

I do, but it's about a cyborg psychiatrist who does way cooler things than I do. Also on hiatus, because his not-as-cool creator has a lot going on.

If you want a non-fiction book or memoir, I don't think I've quite got the material yet. It usually takes a lifetime to build that up. My job is usually (and thankfully) quite boring and mundane most of the time. I seem to come across something worth writing about once every few months or so, and the majority of the time it makes more sense as an essay.

And come to America, specifically Florida, I want to read your multi part write up dealing with our insurance, our minorities, and our whites.

I would if I could! I still harbor hope of moving to the States one day, at this point I would happily trade all the headaches American doctors face for the ones I have, let alone the massively higher pay. If not, I'm sure I'll visit at some point, and I would happily swing by if you'd have me. What's a gator but a very ornery dog? I can handle those just fine.

E: absolutely insane that you still have a Reddit account that’s 11 years old. I find that sort of thing fascinating as well.

Eh, it's there, I mostly use it to lurk these days and occasionally post. The closest I came to violating Reddit's TOS was Motte-posting, and that hasn't been an issue since I migrated here with everyone else. My engagement levels dropped drastically. Even if I had something to say, there are few places I'd want to say it, or where I'd expect a good reception. Culture War? That's here. Less controversial stuff? I happily crosspost.

In general, I think I'm a pretty good citizen by Reddit standards. I've only once been banned, on /r/SSC of all places for tangentially referring to the Motte as the place for CW issues, and that was quickly overturned on polite appeal. For what it's worth, it's less self-censorship than it is the fact that I do not enjoy engaging with the average Redditor.

absolutely insane that you still have a Reddit account that’s 11 years old. I find that sort of thing fascinating as well.

I don't see anything fascinating about that. Many people (including me) have the same distinction.

I’ve been banned 23 separate times (I just checked) and that doesn’t count the immediate auto ban based on IP.

Which says a lot about me of course.

It’s just a story about the ideological drift of the entirety of the internet from libertarian to progressive.

Anyone that can navigate that sort of mind field over the last decade has my respect.

I’ve been banned 23 separate times

Incredible. I barely interacted with reddit and usually lost interest before any given account could be banned, but once one got the hammer, I've never gone back.

It’s easy enough: Only get into politics in languages other than English.

"fright" as sudden freezing + incredibly distressed = looks like ictal fear.

zoomies + sprinting around room + severe biting = motor automatism. can be sign of temporal or frontal seizure. (running around = cursive seizure)

He could not explain why he did this or what he experienced during the episodes. = ? post-ictal amnesia.

liked staying up late = maybe just maybe, he may have an inkling that the episodes are more common in night (=nocturnal seizures).

overall, i am supportive of your CPS diagnosis aka Focal Impaired Awareness seizures. But either primary frontal origin or actual mesial TLE spreading to Frontal. Definitely next step should be EEG if episodes are frequent (or sleep deprived EEG) and/or MRI brain (epilepsy protocol). it may be surgically treatable also.
Call the Resident, if possible.

Thank you for taking the time to write that up! It aligns with what other neurologists have said on Reddit, and my attempts to dig deeper.

liked staying up late = maybe just maybe, he may have an inkling that the episodes are more common in night (=nocturnal seizures).

I didn't get that impression, but I'm not going to make strong claims either way, this clinical assessment was far from ideal. If I had the time, I would have drilled deeper, specifically looking for any temporal patterns, but at the least the mom didn't mention it. In her words, the boy just liked staying up late, and that's more likely to be because he's got a phone.

Call the Resident, if possible.

Sadly, that probably wouldn't help. It is very difficult to contact a patient like that (EMR? What EMR?) and nobody would bother short of an acute emergency. At least we arranged a followup in a month, and I expect that the other doctor will probably be there. I'll drop him a text anyway, just in case it makes a difference!

Fascinating! I am once again in awe of the TV showrunners of House who realised that a medical mystery could be swapped for a crime mystery.

During normal daily activities, the boy would suddenly freeze. He would look incredibly distressed, and then he would get the human equivalent of the zoomies. He would sprint around the room. After the running stopped, he would approach his mother or older sister and bite them. Sometimes he bit hard enough to draw blood. He could not explain why he did this or what he experienced during the episodes.

Aggression related to panic attacks?

I looked at him again. He was a perfectly normal, fidgety kid missing a few baby teeth. There were no obvious signs of hydrophobia, though I mentally filed rabies under "highly unlikely but technically possible."

He'd be dead, wouldn't he? Survival time is usually less than a week after symptoms appear, though I'm surprised to learn you can have morbid rabies for months or years before symptoms show up.

EDIT: google AI lied about its sources but 'within a few days' does seem accurate: https://my.clevelandclinic.org/health/diseases/13848-rabies. Other sources say one to two weeks: https://www.canada.ca/en/public-health/services/diseases/rabies/for-health-professionals.html

Aggression related to panic attacks?

Very unlikely! Even plain old panic attacks would be unusual at that age, let alone such a specific kind of aggression. They're also not usually associated with amnesia or dissociation, more like hyper-focus.

After I posted on /r/Medicine, I had a few actual senior neurologists show up. They lean towards my hypothesis that it's some kind of seizure activity, but there's no consensus on whether it's a temporal lobe one, a different kind of focal seizure such as one affecting the frontal lobe, or if there's a slightly different variant called absence seizures that might be causing sleep issues and poor academic performance. The only real way to know would be an EEG, which would hopefully be identified the next time they attend (I regret not insisting on it, but I was a guest and deferring to those with more local expertise).

He'd be dead, wouldn't he? Survival time is usually less than a week after symptoms appear, though I'm surprised to learn you can have morbid rabies for months or years before symptoms show up.

My mention of rabies was mostly sarcasm. The kid would have a lot of other issues before they (might) end up biting people. It would have been glaringly obvious and even here, with less than perfect triage and routing, very unlikely to show up in the psych OPD. But yes, if it was rabies, he would be done for.

I was about to claim that it's impossible for rabies to be latent for years, but apparently there are a handful of claimed cases?

https://www.nejm.org/doi/full/10.1056/NEJM199101243240401

Rabies infection in these three patients did not originate in the United States but resulted from exposures in Laos, the Philippines, and Mexico. Since the three patients had lived in the United States for 4 years, 6 years, and 11 months, our findings suggest that the onset of the clinical manifestations of rabies occurred after long incubation periods.

I am not sure how much to trust them. Either way, it's rare. But funny excerpt:

The patient's father recalled that the child had been bitten by a neighbor's dog shortly before leaving the Philippines for the United States. The dog was said to have remained healthy and was eaten about a month later.

Makes sense. I was thinking that 'inability to explain' or denial at that age might be simple inarticulacy / fear of adults or authority rather than literal amnesia or dissociation.

The child was quite extroverted and responsive when talking to me or my colleague. If he was the shy type, he's better at hiding it than I am haha.

I can't really comment on his articulacy. My Hindi is far from the best, and his mother was the primary informant. But he sounded... fine?

If this was a once off? Kids do dumb things for no good reason. So do us adults. But the repeated pattern and general picture points towards something in the DSM and not "just a rambunctious boy child". But what precisely? Impossible to answer authoritatively with the information I have at present. I hope I do get to see the followup and final diagnosis, but I wouldn't bet on it.